Abstract: Investigating the damage reduction control and the life cycle prediction of blade for purpose of improving the reliability,usability and maintainability of marine gas turbine need to analyze the structure performance of key components.Finite Element Method was used to carry out the three-dimensional analysis of thermal-fluid-structure interaction with regard to different stress and strain under emergent loading conditions.Experime nt was performed to control the material strain of turbine blade,which would make inputs available for life cycle prediction,followed by stress and strain computation in typical loading spectrum.The results were used f or computing the life cycle of fatigue cracks at two hazardous points by Basquin Equation and Manson-Coffin Equation.Analysis results can be utilized to predict the blades＇ life cycle and thus provide reference for th he operation and maintenance of gas turbine.