Abstract: [Objectives] Based on the numerical simulation of resistance and self-propulsion, the lines optimization of an inland river cruise ship is carried out with resistance and delivered power as the optimization objectives. [Methods] Firstly, the fore ship is optimized with resistance as the optimization objective. Based on the parametric transformation of the fore ship and the CFD calculation of resistance, the optimized hull form 1 is obtained. Then, the aft ship optimization is carried out with delivered power as the optimization objective. The final optimized hull form is obtained through the parametric transformation of the aft ship and the CFD calculation of resistance and self-propulsion. [Results] CFD calculation results show that the effective power of the final optimized hull form is reduced by 5.17% and the delivered power is reduced by 7.11% compared with the initial hull form. [Conclusions] The research shows that the optimization method adopted can effectively improve the resistance and propulsion performance of ships, and can be extended to the optimization of other ship types.