[Objectives] A method for calculating the acoustic and vibration response of underwater cabin structures based on the vibration test results on land is studied. [Methods] An axisymmetric boundary element method is introduced to describe the radiation acoustic field of the shell, then the acoustic radiation impedance matrix of the outer surface of the shell and acoustic transfer vector (ATV) is constructed by solving the numerical solution of the boundary element integral equation. Based on the assumption that the low-order modes of underwater segment structure is the same as that of onshore segment, combined with the modes and acoustic radiation impedance matrix of onshore segment, the modal additional mass and modal additional damping are calculated. [Results] The formula for calculating the natural frequencies of the underwater cabin was derived, and the underwater vibration response of the structure was calculated based on the modal superposition method with the vibration response in the air as the input. Finally, the acoustic radiation characteristics of the structure were obtained. [Conclusions] The numerical results of a typical cabin with internal structure show that the method meets the engineering accuracy requirements.